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      2023                            d  c05/202310aGene Ontology10agene annotation10agene function10aknowledge graphs10aknowledgebase1 aGene Consortium1 aSuzi Aleksander1 aJames Balhoff1 aSeth Carbon1 aMichael Cherry1 aHarold Drabkin1 aDustin Ebert1 aMarc Feuermann1 aPascale Gaudet1 aNomi Harris1 aDavid Hill1 aRaymond Lee1 aHuaiyu Mi1 aSierra Moxon1 aChristopher Mungall1 aAnushya Muruganugan1 aTremayne Mushayahama1 aPaul Sternberg1 aPaul Thomas1 aKimberly Van Auken1 aJolene Ramsey1 aDeborah Siegele1 aRex Chisholm1 aPetra Fey1 aMaria Aspromonte1 aMaria Nugnes1 aFederica Quaglia1 aSilvio Tosatto1 aMichelle Giglio1 aSuvarna Nadendla1 aGiulia Antonazzo1 aHelen Attrill1 aGil Santos1 aSteven Marygold1 aVictor Strelets1 aChristopher Tabone1 aJim Thurmond1 aPinglei Zhou1 aSaadullah Ahmed1 aPraoparn Asanitthong1 aDiana Buitrago1 aMeltem Erdol1 aMatthew Gage1 aMohamed Kadhum1 aKan Li1 aMiao Long1 aAleksandra Michalak1 aAngeline Pesala1 aArmalya Pritazahra1 aShirin Saverimuttu1 aRenzhi Su1 aKate Thurlow1 aRuth Lovering1 aColin Logie1 aSnezhana Oliferenko1 aJudith Blake1 aKaren Christie1 aLori Corbani1 aMary Dolan1 aHarold Drabkin1 aDavid Hill1 aLi Ni1 aDmitry Sitnikov1 aCynthia Smith1 aAlayne Cuzick1 aJames Seager1 aLaurel Cooper1 aJustin Elser1 aPankaj Jaiswal1 aParul Gupta1 aPankaj Jaiswal1 aSushma Naithani1 aManuel Lera-Ramirez1 aKim Rutherford1 aValerie Wood1 aJeffrey De Pons1 aMelinda Dwinell1 aThomas Hayman1 aMary Kaldunski1 aAnne Kwitek1 aStanley Laulederkind1 aMarek Tutaj1 aMahima Vedi1 aShur-Jen Wang1 aPeter D'Eustachio1 aLucila Aimo1 aKristian Axelsen1 aAlan Bridge1 aNevila Hyka-Nouspikel1 aAnne Morgat1 aSuzi Aleksander1 aMichael Cherry1 aStacia Engel1 aKalpana Karra1 aStuart Miyasato1 aRobert Nash1 aMarek Skrzypek1 aShuai Weng1 aEdith Wong1 aErika Bakker1 aTanya Berardini1 aLeonore Reiser1 aAndrea Auchincloss1 aKristian Axelsen1 aGhislaine Argoud-Puy1 aMarie-Claude Blatter1 aEmmanuel Boutet1 aLionel Breuza1 aAlan Bridge1 aCristina Casals-Casas1 aElisabeth Coudert1 aAnne Estreicher1 aMaria Famiglietti1 aMarc Feuermann1 aArnaud Gos1 aNadine Gruaz-Gumowski1 aChantal Hulo1 aNevila Hyka-Nouspikel1 aFlorence Jungo1 aPhilippe Le Mercier1 aDamien Lieberherr1 aPatrick Masson1 aAnne Morgat1 aIvo Pedruzzi1 aLucille Pourcel1 aSylvain Poux1 aCatherine Rivoire1 aShyamala Sundaram1 aAlex Bateman1 aEmily Bowler-Barnett1 aHema Bye-A-Jee1 aPaul Denny1 aAlexandr Ignatchenko1 aRizwan Ishtiaq1 aAntonia Lock1 aYvonne Lussi1 aMichele Magrane1 aMaria Martin1 aSandra Orchard1 aPedro Raposo1 aElena Speretta1 aNidhi Tyagi1 aKate Warner1 aRossana Zaru1 aAlexander Diehl1 aRaymond Lee1 aJuancarlos Chan1 aStavros Diamantakis1 aDaniela Raciti1 aMagdalena Zarowiecki1 aMalcolm Fisher1 aChristina James-Zorn1 aVirgilio Ponferrada1 aAaron Zorn1 aSridhar Ramachandran1 aLeyla Ruzicka1 aMonte Westerfield00aThe Gene Ontology knowledgebase in 2023.0 v2243 a<p>The Gene Ontology (GO) knowledgebase (http://geneontology.org) is a comprehensive resource concerning the functions of genes and gene products (proteins and noncoding RNAs). GO annotations cover genes from organisms across the tree of life as well as viruses, though most gene function knowledge currently derives from experiments carried out in a relatively small number of model organisms. Here, we provide an updated overview of the GO knowledgebase, as well as the efforts of the broad, international consortium of scientists that develops, maintains, and updates the GO knowledgebase. The GO knowledgebase consists of three components: (1) the GO-a computational knowledge structure describing the functional characteristics of genes; (2) GO annotations-evidence-supported statements asserting that a specific gene product has a particular functional characteristic; and (3) GO Causal Activity Models (GO-CAMs)-mechanistic models of molecular "pathways" (GO biological processes) created by linking multiple GO annotations using defined relations. Each of these components is continually expanded, revised, and updated in response to newly published discoveries and receives extensive QA checks, reviews, and user feedback. For each of these components, we provide a description of the current contents, recent developments to keep the knowledgebase up to date with new discoveries, and guidance on how users can best make use of the data that we provide. We conclude with future directions for the project.</p>  a1943-2631