01584nas a2200289   4500000000100000000000100001008004100002260001300043653001200056653002600068653002300094653002800117653002300145653001300168653001100181653003800192653001300230653001300243653002800256653002700284100002000311245005900331300001100390490000700401520087200408022001401280       2010                            d  c2010 Jan10aAnimals10aComputational Biology10aDatabases, Genetic10aDatabases, Nucleic Acid10aDatabases, Protein10aGenomics10aHumans10aInformation Storage and Retrieval10aInternet10aSoftware10aUser-Computer Interface10aVocabulary, Controlled1 aGene Consortium00aThe Gene Ontology in 2010: extensions and refinements.  aD331-50 v383 aThe Gene Ontology (GO) Consortium (http://www.geneontology.org) (GOC) continues to develop, maintain and use a set of structured, controlled vocabularies for the annotation of genes, gene products and sequences. The GO ontologies are expanding both in content and in structure. Several new relationship types have been introduced and used, along with existing relationships, to create links between and within the GO domains. These improve the representation of biology, facilitate querying, and allow GO developers to systematically check for and correct inconsistencies within the GO. Gene product annotation using GO continues to increase both in the number of total annotations and in species coverage. GO tools, such as OBO-Edit, an ontology-editing tool, and AmiGO, the GOC ontology browser, have seen major improvements in functionality, speed and ease of use.  a1362-4962