01941nas a2200325   4500000000100000000000100001008004100002260001200043100001800055700001800073700002600091700001900117700001400136700001900150700001800169700001800187700001500205700001700220700001900237700001400256700001600270700001900286700001800305245009300323856007700416300001300493490000700506520108800513022001401601       2015                            d  c07/20151 aRyan Graebner1 aMitchell Wise1 aAlfonso Cuesta-Marcos1 aMatthew Geniza1 aTom Blake1 aVictoria Blake1 aJoshua Butler1 aShiaomen Chao1 aDavid Hole1 aRich Horsley1 aPankaj Jaiswal1 aDon Obert1 aKevin Smith1 aSteven Ullrich1 aPatrick Hayes00aQuantitative Trait Loci Associated with the Tocochromanol (Vitamin E) Pathway in Barley.  uhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133767  ae01337670 v103 aThe Genome-Wide Association Studies approach was used to detect Quantitative Trait Loci associated with tocochromanol concentrations using a panel of 1,466 barley accessions. All major tocochromanol types- α-, β-, δ-, γ-tocopherol and tocotrienol- were assayed. We found 13 single nucleotide polymorphisms associated with the concentration of one or more of these tocochromanol forms in barley, seven of which were within 2 cM of sequences homologous to cloned genes associated with tocochromanol production in barley and/or other plants. These associations confirmed a prior report based on bi-parental QTL mapping. This knowledge will aid future efforts to better understand the role of tocochromanols in barley, with specific reference to abiotic stress resistance. It will also be useful in developing barley varieties with higher tocochromanol concentrations, although at current recommended daily consumption amounts, barley would not be an effective sole source of vitamin E. However, it could be an important contributor in the context of whole grains in a balanced diet.  a1932-6203