03000nas a2200601   4500000000100000000000100001008004100002260001600043100002300059700002000082700001700102700001600119700002100135700001700156700001500173700001800188700001900206700001700225700001400242700001200256700002000268700002000288700001700308700001800325700001800343700001900361700001600380700001800396700001600414700002100430700001700451700001700468700001700485700001600502700002000518700001300538700002100551700002200572700001600594700001800610700002100628700002400649700001600673700001900689700001900708700001900727700001600746245009000762300001600852490000700868520150900875022001402384       2018                            d  c2018 Jan 041 aMarcela Tello-Ruiz1 aSushma Naithani1 aJoshua Stein1 aParul Gupta1 aMichael Campbell1 aAndrew Olson1 aSharon Wei1 aJustin Preece1 aMatthew Geniza1 aYinping Jiao1 aYoung Lee1 aBo Wang1 aJoseph Mulvaney1 aKapeel Chougule1 aJustin Elser1 aNoor Al-Bader1 aSunita Kumari1 aJames Thomason1 aVivek Kumar1 aDaniel Bolser1 aGuy Naamati1 aElectra Tapanari1 aNuno Fonseca1 aLaura Huerta1 aHaider Iqbal1 aMaria Keays1 aAlfonso Fuentes1 aAmy Tang1 aAntonio Fabregat1 aPeter D'Eustachio1 aJoel Weiser1 aLincoln Stein1 aRobert Petryszak1 aIrene Papatheodorou1 aPaul Kersey1 aPatti Lockhart1 aCrispin Taylor1 aPankaj Jaiswal1 aDoreen Ware00aGramene 2018: unifying comparative genomics and pathway resources for plant research.  aD1181-D11890 v463 aGramene (http://www.gramene.org) is a knowledgebase for comparative functional analysis in major crops and model plant species. The current release, #54, includes over 1.7 million genes from 44 reference genomes, most of which were organized into 62,367 gene families through orthologous and paralogous gene classification, whole-genome alignments, and synteny. Additional gene annotations include ontology-based protein structure and function; genetic, epigenetic, and phenotypic diversity; and pathway associations. Gramene's Plant Reactome provides a knowledgebase of cellular-level plant pathway networks. Specifically, it uses curated rice reference pathways to derive pathway projections for an additional 66 species based on gene orthology, and facilitates display of gene expression, gene-gene interactions, and user-defined omics data in the context of these pathways. As a community portal, Gramene integrates best-of-class software and infrastructure components including the Ensembl genome browser, Reactome pathway browser, and Expression Atlas widgets, and undergoes periodic data and software upgrades. Via powerful, intuitive search interfaces, users can easily query across various portals and interactively analyze search results by clicking on diverse features such as genomic context, highly augmented gene trees, gene expression anatomograms, associated pathways, and external informatics resources. All data in Gramene are accessible through both visual and programmatic interfaces.  a1362-4962