02132nas a2200337   4500000000100000000000100001008004100002260001600043653001200059653001600071653002700087653001800114653002800132653002100160653001800181653001100199653001300210653000900223653003400232653000900266653002900275653002400304653002800328653001400356100002000370245005500390300001400445490000700459520131400466022001401780       2021                            d  c2021 Jan 0810aAnimals10aArabidopsis10aCaenorhabditis elegans10aDictyostelium10aDrosophila melanogaster10aEscherichia coli10aGene Ontology10aHumans10aInternet10aMice10aMolecular Sequence Annotation10aRats10aSaccharomyces cerevisiae10aSchizosaccharomyces10aUser-Computer Interface10aZebrafish1 aGene Consortium00aThe Gene Ontology resource: enriching a GOld mine.  aD325-D3340 v493 a<p>The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computational schema to check and validate the rapidly increasing repository of 2838 GO-CAMs. In addition, we describe the impacts of several collaborations to refine GO and report a 10% increase in the number of GO annotations, a 25% increase in annotated gene products, and over 9,400 new scientific articles annotated. As the project matures, we continue our efforts to review older annotations in light of newer findings, and, to maintain consistency with other ontologies. As a result, 20 000 annotations derived from experimental data were reviewed, corresponding to 2.5% of experimental GO annotations. The website (http://geneontology.org) was redesigned for quick access to documentation, downloads and tools. To maintain an accurate resource and support traceability and reproducibility, we have made available a historical archive covering the past 15 years of GO data with a consistent format and file structure for both the ontology and annotations.</p>
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