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The genome of cyclosporine drug producing fungus Tolypocladium inflatum.

The genome of cyclosporine (synonym: cyclosporin) drug producing fungus Tolypocladium inflatum was published recently by Bushley et al. (2013), in the journal PLOS Genetics. The genome sequencing and its annotation discovered a cyclosporin biosynthesis associated metabolite gene cluster. "Cyclosporin is a powerful immunosupressant with a specific action on T-lymphocyte cells. It is widely used for the prophylaxis of graft rejection in organ and tissue transplants in human subjects" (source: NIH-PubChem). Jaiswal lab contributed in this collaborative project.

Reference citation:
Bushley KE, Raja R, Jaiswal P, Cumbie JS, Nonogaki M, Boyd AE, Owensby CA, Knaus BJ, Elser J, Miller D, Di Y, McPhail KL, Spatafora JW. PLoS Genet. 2013 Jun;9(6):e1003496. doi: 10.1371/journal.pgen.1003496 [View publication